Episode 2 - Identify the Identifier!
Sign up for free
Listen to this episode and many more. Enjoy the best podcasts on Spreaker!
Download and listen anywhere
Download your favorite episodes and enjoy them, wherever you are! Sign up or log in now to access offline listening.
Description
Welcome to the 2nd episode of Bytes of Bio, Identify the Identifier! Tadaa~ It's the TATA box. Boy, if you found the first episode hard, wait until you listen to...
show moreTadaa~ It's the TATA box. Boy, if you found the first episode hard, wait until you listen to this one. Statistically, I can confirm that 50% of the hosts on the show didn't understand 80% of it.
Let’s go through the main points we have discussed!
Goal: Identify the start of a genetic sequence (TATA box) to better study it.
TATA box: a non-coding sequence that helps the RNA polymerase identify where to start transcription.
Naive Bayes (in detecting TATA box): takes into account the characteristics of a TATA box and calculate the possibility that a string of TAs is actually a TATA box.
Improvements to Naive Bayes:
Improve the prediction accuracy by perturbing the computed prior probabilities.
Take into account dependency between factors that determine a TATA box.
Reference links mentioned throughout the podcast:
Case study for this episode, Extensions of Naive Bayes and Their Applications to Bioinformatics, study by Raja Loganantharaj, University of Louisiana, Lafayette (https://drive.google.com/file/d/1QXQHr8iCwDOTdy-u055MvBDARYNjdESY/view)
TATA box (http://bio1151.nicerweb.com/Locked/media/ch17/17_08TranscripInitiation.jpg)
Explanation of Naive Bayes (https://monkeylearn.com/blog/practical-explanation-naive-bayes-classifier/)
Limited dependency (https://cdn-images-1.medium.com/max/800/1*cdvfzvpkJkUudDEryFtCnA.png)
If you like this episode please leave a rating or a review!
It gets easier... I promise... Just, strap yourself in for next week's...
Information
Author | May |
Organization | May |
Website | - |
Tags |
Copyright 2024 - Spreaker Inc. an iHeartMedia Company