🏈 Iowa State Cyclones vs Oklahoma State Cowboys picks, predictions and odds for their Big 12 showdown on Saturday, October 24, 2020, at 3:30 p.m. ET from Boone Pickens Stadium in Stillwater, Oklahoma. Direct from Las Vegas, our panel of professional sports handicappers look at the Vegas odds and give their college football football expert picks and predictions on the matchup between the Cyclones and Cowboys. Current college football odds from Las Vegas have Oklahoma State as a -3.5 home favorite over Iowa State, with the over/under sitting at 52 points.

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