Clemson Tigers vs Florida State Seminoles picks, predictions and odds for their ACC football showdown on Saturday, November 21, 2020, at 12:00 p.m. ET from Doak Campbell Stadium in Tallahassee, Florida. Direct from Las Vegas, our panel of professional sports handicappers look at the Vegas odds and give their college football football expert picks and predictions on the matchup between the Tigers and Seminoles. Current college football odds from Las Vegas have Clemson as a 35-point road favorite over Florida State, with the over/under sitting at 63.5 points.

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