Prostate cancer (PCa) is the second leading cause of cancer death in American men, behind lung cancer and it predominately affects elderly men with higher incidence. About 1 man in 41 will die of prostate cancer. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the appearance of castration-resistant PCa (CRPCa), which leads to a poor prognosis in patients. https://www.antibody-creativebiolabs.com/prostate-cancer-overview-signaling-pathway.htm