27 JAN 2021 · Application of Recombinant Antibody (rAb): desire or requirement for a short circulating half-life in serum; a smaller biologic that would have broader tissue distribution or the ability to penetrate tumors; a molecule that can be manufactured in either yeast or E. coli to potentially reduce cost of goods or increase scale of manufacturing; a molecule lacking an Fc effector functionality to eliminate both cellular responses against the target and potential for dimerization of receptors due to bivalency; a bispecific antibody fragment, such as has been demonstrated by BiTEs (bispecific T cell engagers; diabodies and most recently, DARTs; a molecule lacking an Fc effector functionality to eliminate both cellular responses against the target and potential for dimerization of receptors due to bivalency; a molecule that can be manufactured in either yeast or E. coli to potentially reduce cost of goods or increase scale of manufacturing. https://www.creative-biolabs.com/recombinant-antibody.html

27 JAN 2021 · Over expression of some targets in a cell-based system is difficult due to the fast degradation or cytotoxicity to host cells, in vitro protein expression is becoming more and more attractive. https://www.creative-biolabs.com/cell-free-protein-expression-kits.html

27 JAN 2021 · Recombinant antibodies are antibody fragments generated by using recombinant antibody coding genes as a source and display technology, delivering high reproducibility, specificity and scalability. Unlike monoclonal antibodies (mAbs) which are produced using traditional hybridoma technologies, rAbs do not need hybridomas and animals in the production process if you only use synthetic genes.https://www.creative-biolabs.com/monoclonal-mouse-antibody-production.html

27 JAN 2021 · https://www.creative-biolabs.com/resource/pdf/com/infographics/Development-of-Monoclonal-Antibodies-Creative-Biolabs.pdf

27 JAN 2021 · What are recombinant antibodies? Recombinant antibodies are antibody fragments generated by using recombinant antibody coding genes as a source and display technology, delivering high reproducibility, specificity and scalability. Unlike monoclonal antibodies (mAbs) which are produced using traditional hybridoma technologies, rAbs do not need hybridomas and animals in the production process if you only use synthetic genes.https://www.creative-biolabs.com/

27 JAN 2021 · Phage display is one of the most powerful and widely used laboratory technique for the study of protein-protein, protein-peptide and protein-DNA interactions. This technology is mainly based on displaying the interest protein (peptides, antibodies, scaffolds or others) on the surface of employing phage and then be used to interrogate the constructed libraries containing millions or even billions of displayed phages. https://www.creative-biolabs.com/phage-display-service.html

27 JAN 2021 · Bacterial display (or bacteria display or bacterial surface display) is a protein engineering technique widely used for in vitro protein evolution. https://www.creative-biolabs.com/bacterial-display-platform.html

27 JAN 2021 · Purified monoclonal antibodies in multivalent forms can be sequenced with 100% coverage of the desired regions as well as excellent accuracy. https://www.creative-biolabs.com/next-generation-antibody-sequencing.html

27 JAN 2021 · Phage display technology is one of the major approaches employed in various protein interaction studies, especially in the discovery of specific antibodies, scaffolds or ligands. While binders with the desired specificity generally exist at low frequencies in the constructed libraries. In this way, phage display library screening has become an effective technique for the enrichment and identification of binders with high affinity and specificity from interested libraries. https://www.creative-biolabs.com/phage-display-library-screening.html

27 JAN 2021 · Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system. https://www.creative-biolabs.com/antibody-humanization.html