chimeric antigen receptor
Nov 29, 2018 ·
1m 10s
The typical structure of a chimeric antigen receptor molecule includes a single chain variable fragment (scFv), a spacer, a transmembrane domain (TM) and an intracellular signaling domain. The scFv is...
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The typical structure of a chimeric antigen receptor molecule includes a single chain variable fragment (scFv), a spacer, a transmembrane domain (TM) and an intracellular signaling domain. The scFv is derived from monoclonal antibody (mAb), which can specifically recognize the target protein on tumor surface and subsequently transduct activation signal into CAR-T cell.
Due to the linkage between the T cell activation and the expression and function of the CARs, we would obtain functional CARs with high affinities ranging from 10 pmol to nmol. Notably, we have generated several CAR-T libraries not only for blood cancer antigen CD19, but also for solid tumors against different antigens, such as Her2, Her3, EGFR, FGFR1, VEGFR, etc. The selected stable clones can be used in clinic trials immediately, thus making this CAR T technology more powerful and attractive in CAR-T cell immunotherapy. https://www.creative-biolabs.com/car-t/cellrapeutics-chimeric-antigen-receptor-car-technology.htm
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Due to the linkage between the T cell activation and the expression and function of the CARs, we would obtain functional CARs with high affinities ranging from 10 pmol to nmol. Notably, we have generated several CAR-T libraries not only for blood cancer antigen CD19, but also for solid tumors against different antigens, such as Her2, Her3, EGFR, FGFR1, VEGFR, etc. The selected stable clones can be used in clinic trials immediately, thus making this CAR T technology more powerful and attractive in CAR-T cell immunotherapy. https://www.creative-biolabs.com/car-t/cellrapeutics-chimeric-antigen-receptor-car-technology.htm
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| Author | Bella Smith |
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