Intermittent Fasting: does it even work? A new study casts doubt on Intermittent Fasting, but is it robust? A look at the science on Intermittent Fasting.

Intermittent Fasting is incredibly popular. People report weight loss, improved glucose metabolism, lower cholesterol, etc

Just less calories or specific benefit of fasting?

is eating less every day just as good as fasting, or does fasting deliver some special benefit?

popular books promise specific benefits of fasting, autophagy, and therefore we should all fast to get those benefits

when matching for calories, Intermittent Fasting wasn't any better than eating less calories

so who’s right? What’s the truth?

new study had volunteers fast without caloric deficit. does fasting deliver special metabolic benefit aside from calories?

2nd expt: 2 groups eat 25% less calories, one fasting, one not, if fasting is special we should see an advantage of the intermittent fasting group

intermittent fasting protocol inhibited fat loss
Why would they lose less fat if they’re eating the same calories?

fasted group had less physical activity. not an absolute limitation of fasting. "main practical message if planning to use alternate-day fasting is to consciously insert physical activity”

meta-analysis: intermittent fasting vs continuous energy restriction:
“no apparent superiority of a dietary regimen”

meta: intermittent fasting comparable to continuous energy restriction

review: intermittent fasting appears equivalent to daily energy restriction

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References:
https://www.science.org/doi/epdf/10.1126/scitranslmed.abd8034
https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-018-1748-4.pdf
https://pubmed.ncbi.nlm.nih.gov/29419624/
https://pubmed.ncbi.nlm.nih.gov/31023390/
https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.22345
https://www.frontiersin.org/articles/10.3389/fnut.2020.586036/full
https://www.mdpi.com/2072-6643/12/8/2349
https://www.nature.com/articles/ijo2017206.pdf

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