The series is based on Carl Weber’s popular crime drama. Carl Weber's The Family Business follows the Duncans, a prominent family from Jamaica, Queens living fast and luxurious. By day, they’re an upstanding family; by night, they live a dangerous secret life. The patriarch of the family, L.C. Duncan (Hudson), is at the age when he’s starting to think about retirement and has to decide which of his children should take over his thriving exotic car dealership. The Duncans quickly come under siege from some of the top politicians, mafia and drug cartels in the city. The Duncans will have to stick together or die separately. Ernie Hudson is a character actor perhaps best known for his roles as Winston Zeddemore in the Ghostbusters film series, Sergeant Darryl Albrecht in The Crow, and Warden Leo Glynn on HBO’s Oz. In Carl Weber's The Family Business, he plays L.C. Duncan, the patriarch and CEO of the Duncan family business.

Valarie Pettiford is a stage and television actress, dancer, and jazz singer. She received a Tony® nomination for her role in the Broadway production of Fosse. She is also known for her role as "Big Dee Dee" Thorne on the sitcom Half & Half.In Carl Weber's The Family Business she plays Charlotte “Chippy” Duncan, the Duncan family matriarch who keeps the family together no matter the challenges.