SHR # 2466 :: The Pep Talk: Treating Major Depressive Disorder With peptides - Dr. Elizabeth Yurth, MD - The #1 reason people contact me about peptides is asking if there are any that can treat depression. Now I can say yes. . Treating depression is not only difficult, but often doesn’t work at all. Up to 30% of those prescribed SSRI’s say they didn’t work. Ever notice some people NEVER get depressed? Not just hiding it well, but seriously never get depressed? That may be due to the elevated expression a peptide known as Spadin that literally makes them immune to depression. Now you may be able to leverage this peptide to solve your own depression problems.