🏈 Notre Dame Fighting Irish vs Louisville Cardinals picks, predictions and odds for their ACC showdown on Saturday, October 17, 2020, at 2:30 p.m. ET from Notre Dame Stadium in South Bend, Indiana. Direct from Las Vegas, our panel of professional sports handicappers look at the Vegas odds and give their college football football expert picks and predictions on the matchup between the Fighting Irish and Cardinals. Current college football odds from Las Vegas have Notre Dame as a 17-point home favorite over Louisville, with the over/under sitting at 64 points.

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