In vivo phage display is a unique high-throughput method for biopanning by which the peptide phage libraries are directly injected into animals for isolating and identifying the phages bound to specific tissues. Compared with other panning methods, the targets used for isolating phage-displayed peptides are more “intact” with the natural molecular structure and are in the functional states in vivo. Those selected peptides can be used as selective protein transduction domains (PTD) or cell-penetrating peptides (CPPs) for transporting chemotherapeutic agents to the specific tissue, thus improving drug specificity and efficacy in reducing toxicity. Furthermore, some selected peptides can block the function of their ligand proteins by themselves. Using this method, we can offer the functional analysis of new receptors and potential identification and development of novel drug target candidates for the customers.

http://www.creative-biolabs.com/In-vivo-Phage-Display-Service.htm