The March Madness tournament is arranged so that the favored teams, the number one seeds, have the easiest path to the Final Four. This makes the odds even steeper for underdogs. But when an underdog does win, such a victory is all the more inspiring.

One of the biggest tournament upsets in history occurred in 2012, when Norfolk State, a number 15 seed, knocked out Missouri, a number 2 seed, in the first round. Missouri had been favored by 21.5 points—a large advantage for a March Madness game.