Part two of our purrpodcast with Dr. Jessica Quimby, we pick up from where we left and answer the why FDA-approved dermal application of mirtazapine works the way it does. As pilling cats is truly difficult and we do not see as many side effects compared to the oral route, a dermal application makes a lot of sense. Jessica explains how to apply the drug and if we should worry about human exposure. Although it was originally meant to be an antidepressant in people, its current use is mainly as anti-emetic, improving weight gain and appetite stimulant. In cats, the FDA-approved transdermal mirtazapine is classified as a weight gain drug for the management of weight loss. Jessica has no problem giving the drug for longer periods. This episode is made possible by an educational grant of KindredBio.