Glenn Wilson played all or part of ten seasons in the Majors between 1982 and 1993, for the Detroit Tigers, Philadelphia Phillies, Seattle Mariners, Pittsburgh Pirates, and Houston Astros. He was primarily used as a right fielder.

Wilson was selected in the 1st round (18th pick) of the 1980 amateur draft by the Tigers. He made his major league debut on April 15, 1982.

Wilson was best known for his strong throwing arm, and he led all National League outfielders for assists in 1985, 1986, and 1987, throwing out 18 and 20 base-runners from right field, respectively. In 1987, Wilson three times threw out base runners who attempted to reach first base after apparent singles into right field.

On September 15, 1988, Wilson hit two home runs off Randy Johnson, the first two homers ever surrendered by Johnson. At the start of the following season, Wilson again tagged Johnson for a homer.