At Creative Biolabs, the proprietary protocol and tailored biopanning strategy allow the increase of candidates with higher affinity and desired specificity (e.g. binders recognize conformational epitope rather than linear epitope). In general, by conducting four rounds library screening, our scientists can select scFv/Fab antibodies with the affinity of 10-7. Through constructing serial sub-libraries of the isolated scFv/Fab antibodies, we can increase the affinity from 10-8 to 10-9. Moreover, Creative Biolabs has successfully obtained a scFv antibody with an extremely high affinity of 10-12.
https://www.creative-biolabs.com/phage-display-library-screening.html