https://www.mds-foundation.org/podcast/mds-professional-report/The explosion of information on MDS forces us to seek novel, alternative ways to distribute it. Podcasts gives us an easy and popular way to communicate this information in a short time.]]>enMedicineCopyright PI Mediahttps://d3wo5wojvuv7l.cloudfront.net/t_rss_itunes_square_1400/images.spreaker.com/original/7b8bc7d62bbbfefa1a0c2f97a3d163fe.jpghttps://www.mds-foundation.org/podcast/mds-professional-report/Mon, 27 Jul 2026 10:16:38 +0000MDS FoundationPI Mediaran@podil.netMDS official podcastThe explosion of information on MDS forces us to seek novel, alternative ways to distribute it. Podcasts gives us an easy and popular way to communicate this information in a short time.]]>false4e7b2982-fdf4-53e6-8e32-d2a88e858defepisodichttps://www.spreaker.com/episode/pathogenesis-and-inflammaging-in-mds-mds-professional-report--63341250




]]>https://api.spreaker.com/episode/63341250Sat, 01 Feb 2025 04:00:07 +0000MDS FoundationDr. Moshe Mittelman is hosting the world-leading expert Dr. Michael Savona and they have an attractive conversation on several mechanisms involved in the pathogenesis of MDS, including the interaction between genetics, inflammation and aging.   




]]>1727false41fullhttps://www.spreaker.com/episode/treatment-of-lower-risk-mds-mds-professional-report--62541786https://api.spreaker.com/episode/62541786Sun, 15 Dec 2024 04:00:08 +0000MDS FoundationProf. Uwe Platzbecker from Leipzig and Prof. Moshe Mittelman from Tel-Aviv in an interesting conversation on the various available therapeutic modalities for patients with lower-risk MDS.1737false34fullhttps://www.spreaker.com/episode/treatment-for-higher-risk-mds-mds-professional-report--62541651https://api.spreaker.com/episode/62541651Sun, 01 Dec 2024 11:06:30 +0000MDS FoundationProf. Nicolaus Kröger from Hamburg and Prof. Moshe Mittelman from Tel-Aviv, in a stimulating conversation on the various therapeutic modalities, including hematopoietic transplantation, in patients with higher-risk MDS.1729false33fullhttps://www.spreaker.com/episode/update-on-higher-risk-mds-lessons-from-2023-ash-mds-professional-report--60185623https://api.spreaker.com/episode/60185623Mon, 27 May 2024 09:43:24 +0000MDS FoundationDr. Nicolaos Papadantonakis from Emory Atlanta and Dr. Moshe Mittelman from Tel-Aviv, describe several updated abstracts from 2023 ASH with a special focus on Higher-risk MDs, and providing their take home messages.1309false32fullhttps://www.spreaker.com/episode/new-trials-to-address-the-anemia-of-lower-risk-mds-mds-professional-report--59194817https://api.spreaker.com/episode/59194817Wed, 27 Mar 2024 12:41:56 +0000MDS FoundationDrs Nikolaos Papadantonakis of Emory, Atlanta, US, and Moshe Mittelman, Tel-Aviv, Israel, discuss trials presented in American Society of Hematology (ASH) 2023 meeting. They provide some data on luspatercept, imetelstat, roxodustat and Ker-050.  1678false31fullhttps://www.spreaker.com/episode/transfusions-and-quality-of-life-mds-professional-report--53693534https://api.spreaker.com/episode/53693534Mon, 01 May 2023 10:00:02 +0000MDS FoundationProf. Rena Buckstein from Toronto, and Prof. Moshe Mittelman from Tel-Aviv discuss issues related to RBC transfusions, the hemoglobin threshold for transfusion and related quality of life issues.1309false24fullhttps://www.spreaker.com/episode/bone-marrow-failure-disorders-in-childhood-mds-professional-report--52098703https://api.spreaker.com/episode/52098703Mon, 05 Dec 2022 13:11:10 +0000MDS FoundationProf. Akiko Shimamura of Harvard Medical School, Boston, a world known expert of pediatric hematology discusses with Prof. Guillermo Sanz ,of Valencia and Prof. Moshe Mittelman, of Tel Aviv, the various aspects of bone marrow failure including...1351false23fullhttps://www.spreaker.com/episode/the-role-of-genetics-in-mds-management-mds-professional-report--51403340https://api.spreaker.com/episode/51403340Wed, 28 Sep 2022 07:23:28 +0000MDS FoundationDrs. Rafael Bejar (San Diego) and Moshe Mittelman (Tel Aviv) discuss several papers highlighting the role of genetics in MDS diagnosis, follow up and prediction of treatment. They also discuss the role of the newly approved luspatercept in the...1322false22fullhttps://www.spreaker.com/episode/mds-in-ash-2021-are-we-already-in-the-molecular-era-mds-professional-report--48609041Merkel, of the Sheba Medical Center, both from Tel Aviv University, Israel,
discuss several important presentations from the recent 2021 ASH meeting.
They focus on the new IPSS-M classification, discuss the approach to the
MDS patient who is currently defined by IPSS/R as belonging to the /lower-
risk group but in fact the disease behaves like a higher-risk. Finally, they
discuss issues regarding the treatment of patients with HR-MDS: What can be
added to hypomethylating agents ? Targeted therapy with IDH1/2 inhibition
and more…]]>https://api.spreaker.com/episode/48609041Sun, 06 Feb 2022 08:45:22 +0000MDS FoundationDrs. Moshe Mittelman, of The Tel Aviv Sourasky Medical Center, and Drorit Merkel, of the Sheba Medical Center, both from Tel Aviv University, Israel, discuss several important presentations from the recent 2021 ASH meeting. They focus on the new...Merkel, of the Sheba Medical Center, both from Tel Aviv University, Israel,
discuss several important presentations from the recent 2021 ASH meeting.
They focus on the new IPSS-M classification, discuss the approach to the
MDS patient who is currently defined by IPSS/R as belonging to the /lower-
risk group but in fact the disease behaves like a higher-risk. Finally, they
discuss issues regarding the treatment of patients with HR-MDS: What can be
added to hypomethylating agents ? Targeted therapy with IDH1/2 inhibition
and more…]]>2172false21fullhttps://www.spreaker.com/episode/do-immune-check-inhibitors-have-a-role-in-the-treatment-of-higher-risk-mds-mds-professional-report--46630644The combination of azacitidine and pembrolizumab may be a potential effective regimen for patients with higher-risk MDS and may lead to the introduction of an important class of medications into MDS practice

Nazha, Prog model – JCO
A personalized prediction model, based on clinical and genomic data, outperformed established prognostic models in MDS. The use of digital tools allow us to manage big data taken from large numbers of patients and include them in the newly developed diagnostic and prognostic models.


Keundgen , t-MDS- Leukemia
Therapy-related MDS should be classified as a separate entity distinct from other WHO-classified t-myeloid neoplasms, which would enhance treatment decisions and facilitate the inclusion of t-MDS patients into clinical studies.


Strapatsas, PLT, Ann Hem

The authors re-confirm the importance of PLT count as a prognostic factor in MDS, both at presentation and during the disease course. Bleeding is a leading (3rd ) cause of death in these patients.]]>https://api.spreaker.com/episode/46630644Wed, 22 Sep 2021 07:29:10 +0000MDS FoundationChien Aza – Pembro - BJH The combination of azacitidine and pembrolizumab may be a potential effective regimen for patients with higher-risk MDS and may lead to the introduction of an important class of medications into MDS practice Nazha, Prog model...The combination of azacitidine and pembrolizumab may be a potential effective regimen for patients with higher-risk MDS and may lead to the introduction of an important class of medications into MDS practice

Nazha, Prog model – JCO
A personalized prediction model, based on clinical and genomic data, outperformed established prognostic models in MDS. The use of digital tools allow us to manage big data taken from large numbers of patients and include them in the newly developed diagnostic and prognostic models.


Keundgen , t-MDS- Leukemia
Therapy-related MDS should be classified as a separate entity distinct from other WHO-classified t-myeloid neoplasms, which would enhance treatment decisions and facilitate the inclusion of t-MDS patients into clinical studies.


Strapatsas, PLT, Ann Hem

The authors re-confirm the importance of PLT count as a prognostic factor in MDS, both at presentation and during the disease course. Bleeding is a leading (3rd ) cause of death in these patients.]]>1424false14fullhttps://www.spreaker.com/episode/will-venetoclax-become-the-new-standard-mds-professional-report--45162396https://mds-professional-report.castos.com/podcasts/21789/episodes/will-venetoclax-become-the-new-standard-mds-professional-reportWed, 02 Jun 2021 06:56:00 +0000MDS FoundationWe will discuss the addition of venetoclax to hypomethylating agents in the treatment of advanced myeloid neoplasms, especially higher-risk myelodysplastic syndromes.We will then report a study testing the efficacy and safety of imetelstat, a new...2089false13fullhttps://www.spreaker.com/episode/don-t-withhold-anti-neoplastic-treatment-from-your-hematological-patients-infected-by-covid-mds-professional-report--45162402Paper 2Authors: P. Fenaux; U. Platzbecker; A. List and colleagues, multicenterTitle: Luspatercept in Patients with Lower-Risk Myelodysplastic SyndromesDescription: Luspatercept, an activin receptor derived agent, improves the anemia in LR-MDS patients. Thus, we have another approved anti-anemic agent in addition to ESAs for these patients.
Paper 3Authors: David Henry et al. , multicenter ((Disclosure – I am a co-author)Title: Oral Roxadustat Demonstrates Efficacy in Anemia Secondary to Lower-Risk Myelodysplastic Syndrome Irrespective of Ring Sideroblasts and Baseline Erythropoietin LevelsDescription: Roxadustat, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, is another investigated effective agent for the anemia in LR-MDS.
Paper 4Title:  Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AMLAuthors: M.A. Sekeres, and colleagues, multicenter, multunationalDescription:  Pevonedistat, a NEDD8 inhibitor, together with azacitidine, improves the response and prognosis in HR-MDS patients.]]>https://mds-professional-report.castos.com/podcasts/21789/episodes/don39t-withhold-anti-neoplastic-treatment-from-your-hematological-patients-infected-by-covid-mds-professional-reportTue, 30 Mar 2021 08:47:00 +0000MDS FoundationPAPER 1Authors: Vijenthira A. et al. (Princess Margaret, Toronto)Title: Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patientsDescription:⦁ About a third of hospitalized adult patients...Paper 2Authors: P. Fenaux; U. Platzbecker; A. List and colleagues, multicenterTitle: Luspatercept in Patients with Lower-Risk Myelodysplastic SyndromesDescription: Luspatercept, an activin receptor derived agent, improves the anemia in LR-MDS patients. Thus, we have another approved anti-anemic agent in addition to ESAs for these patients.
Paper 3Authors: David Henry et al. , multicenter ((Disclosure – I am a co-author)Title: Oral Roxadustat Demonstrates Efficacy in Anemia Secondary to Lower-Risk Myelodysplastic Syndrome Irrespective of Ring Sideroblasts and Baseline Erythropoietin LevelsDescription: Roxadustat, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, is another investigated effective agent for the anemia in LR-MDS.
Paper 4Title:  Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AMLAuthors: M.A. Sekeres, and colleagues, multicenter, multunationalDescription:  Pevonedistat, a NEDD8 inhibitor, together with azacitidine, improves the response and prognosis in HR-MDS patients.]]>1819false12fullhttps://www.spreaker.com/episode/tp53-mutations-were-they-born-equal-mds-professional-report--45162397Sallman DA et al:A recent study led by Dr. David Sallman tested the efficacy of the combination azacitidine and eprenetapopt (formerly APR-246), a TP53-Mutant activator, in patients with higher-risk MDS.
Goll JB et al:One of the more interesting presentations in the last ASH 2020, was that of Dr. Yohannes Goll and others. They showed that adding molecular analysis they can improve the diagnostic accuracy. Indeed 7 genes significantly reduced pathological misclassification.
Platzbecker U et al:A group of international investigators, led by Dr. Uwe Platzbecker, from Leipzig, reported in last ASH (2020) their encouraging experience with imetelstat, a telomerase-inhibitor to improve anemia in lower-risk MDS patients after ESA failure.]]>https://mds-professional-report.castos.com/podcasts/21789/episodes/tp53-mutations-were-they-born-equal-mds-professional-reportThu, 25 Feb 2021 13:19:00 +0000MDS FoundationBernard E et al: In the first presented study, Dr. Elza Bernard and colleagues deliver an important lesson about the high-risk mutation TP53. That is: not all of them are infeed associated with poor prognosis. Sallman DA et al:A recent study led by...Sallman DA et al:A recent study led by Dr. David Sallman tested the efficacy of the combination azacitidine and eprenetapopt (formerly APR-246), a TP53-Mutant activator, in patients with higher-risk MDS.
Goll JB et al:One of the more interesting presentations in the last ASH 2020, was that of Dr. Yohannes Goll and others. They showed that adding molecular analysis they can improve the diagnostic accuracy. Indeed 7 genes significantly reduced pathological misclassification.
Platzbecker U et al:A group of international investigators, led by Dr. Uwe Platzbecker, from Leipzig, reported in last ASH (2020) their encouraging experience with imetelstat, a telomerase-inhibitor to improve anemia in lower-risk MDS patients after ESA failure.]]>1724false11full