https://www.spreaker.com/podcast/create-podcast--2845933enHealth & FitnessCopyright CReATe Consortiumhttps://d3wo5wojvuv7l.cloudfront.net/t_rss_itunes_square_1400/images.spreaker.com/original/304f436c9370c5ce5056406549ff413e.jpghttps://www.spreaker.com/podcast/create-podcast--2845933Fri, 07 Aug 2026 14:21:18 +0000CReATe ConsortiumCReATe Consortiumfeeds@spreaker.comCReATe Connect podcasts are short recorded interviews on topics we hope will be of interest to patients with ALS and other motor neuron diseases.falseepisodichttps://www.spreaker.com/episode/als-untangled-series-ep-67-alpha-lipoic-acid--73619008https://api.spreaker.com/episode/73619008Fri, 07 Aug 2026 14:21:12 +0000CReATe ConsortiumAlpha-lipoic acid (ALA) is a naturally occurring fatty acid. It has several plausible mechanisms for slowing ALS progression. Preclinical studies showed ALA slowed motor function decline. Some patients reported improvement when taking ALA together...601ala,alphalipoicacid,als,alternativetherapy,caregiver,health,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-19-dr-paul-lingor-on-fasudil-as-a-potential-therapeutic-for-als--72742807]]>https://api.spreaker.com/episode/72742807Wed, 01 Jul 2026 11:05:08 +0000CReATe ConsortiumPaul Lingor, MD, is Professor for Neurology, Group Leader and Head of the Outpatient Clinics for Motoneuron Disorders and Co-head of the Outpatient Clinics for Movement Disorders and at the Department of Neurology of the TUM Klinikum Rechts der Isar...]]>2471als,biomarkers,clinicaltrial,fasudil,health,mnd,munix,neurology,research,rock-inhibition,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-66-pons--72320854https://api.spreaker.com/episode/72320854Wed, 03 Jun 2026 14:10:52 +0000CReATe ConsortiumPortable Neuromodulation Stimulator (PoNS) is a type of electrical stimulation that can theoretically increase rewiring in the brain (neuroplasticity).  Small trials suggest that it can improve walking in MS but thus far there are no data in people...600als,alternativetherapy,caregiver,health,mnd,neurology,patient,pons,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-65-isrib--72021108https://api.spreaker.com/episode/72021108Fri, 15 May 2026 14:47:51 +0000CReATe ConsortiumISRIB stands for “integrated stress response inhibitor).  As we discuss here, it is an oral medication that inhibits an intracellular pathway called the integrative stress response pathway.  It is not FDA approved for any condition but is available in...658als,alternativetherapy,caregiver,health,isrib,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-18-dr-michael-benatar-on-mmi-as-a-prodromal-stage-of-als--71211908https://api.spreaker.com/episode/71211908Thu, 09 Apr 2026 14:54:42 +0000CReATe ConsortiumDr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “Proposed Research Criteria for Mild Motor Impairment...1835als,ftd,health,mmi,mnd,neurology,presymptomatic,prodromal,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-17-ai-generated-podcast-on-c9orf72-disease-prevention-trials--69355036https://api.spreaker.com/episode/69355036Thu, 08 Jan 2026 15:13:36 +0000CReATe ConsortiumHere we have a podcast produced by artificial intelligence discussing the recent publication “Design considerations for C9orf72 disease prevention trials”. 1564als,biomarker,c9orf72,ftd,health,mnd,neurology,phenoconversion,pre-symptomatic,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-64-wahls-protocol--68979473https://api.spreaker.com/episode/68979473Wed, 10 Dec 2025 17:47:33 +0000CReATe ConsortiumThe Wahls Protocol is a diet that may reduce inflammation, oxidative stress, and mitochondrial dysfunction.  Although these are plausible mechanisms for slowing ALS progression, we discuss the fact that there are no actual data to support this...1004als,alternativetherapy,caregiver,health,mnd,neurology,patient,science,supplement,thewahlsprotocolfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-63-psilocybin--68604876https://api.spreaker.com/episode/68604876Mon, 17 Nov 2025 16:39:31 +0000CReATe ConsortiumPsilocybin is a psychedelic chemical derived from mushrooms.  It is under study for mood problems in people with ALS.  Here we review its plausible mechanisms for slowing ALS progression.  But there are no data from preclinical models, trials or case...570als,alternativetherapy,caregiver,diet,health,mnd,neurology,patient,psilocybin,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-62-ashwagandha--68212625https://api.spreaker.com/episode/68212625Mon, 20 Oct 2025 12:00:03 +0000CReATe ConsortiumHere we review ashwagandha a nutritional supplement that has plausible mechanisms for slowing ALS, promising pre-clinical evidence, and a reasonable safety profile.  There is one person with ALS who experienced a reversal of symptoms on a cocktail of...1010als,alternativetherapy,ashwagandha,caregiver,health,mnd,neurology,patient,science,supplementfalsefullhttps://www.spreaker.com/episode/create-author-series-ep-16-dr-johnathan-cooper-knock-on-exercise-and-als--67877239https://api.spreaker.com/episode/67877239Wed, 24 Sep 2025 13:13:49 +0000CReATe ConsortiumDr. Johnathan Cooper-Knock is a neurologist and clinical lecturer at the University of Sheffield.  His research focuses on genetic causes of ALS.  Here he discusses his recent publication “Extreme exercise in males is linked to mTOR signalling and...1161als,exercise,gene-environment,health,mnd,mtor,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-61-zinc--67692061https://api.spreaker.com/episode/67692061Tue, 09 Sep 2025 16:33:29 +0000CReATe ConsortiumHere we review Zinc supplements as a treatment for ALS.  These are inexpensive, reasonably safe at certain doses, and are easy to acquire.  They have plausible mechanisms by which they could slow ALS progression.  However, the data from people living...1034als,alternativetherapy,caregiver,health,mnd,neurology,patient,science,supplement,zincfalsefullhttps://www.spreaker.com/episode/create-author-series-ep-15-drs-terry-heiman-patterson-and-michael-benatar-on-clinical-guidance-for-als-ftd-at-risk-carriers--66369507]]>https://api.spreaker.com/episode/66369507Mon, 02 Jun 2025 15:54:44 +0000CReATe ConsortiumDr. Terry Heiman-Patterson is a neurologist and professor at Temple University and the director of the Center for Neurodegenerative Disorders and the MDA/ALS Center of Hope.  Dr. Michael Benatar is a Professor of Neurology and Chief of the...]]>1972als,als/ftd,ftd,health,neurogenetics,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-14-drs-ruben-van-eijk-and-michael-benatar-on-phase-2-trials-and-als--65828233https://api.spreaker.com/episode/65828233Thu, 01 May 2025 16:48:11 +0000CReATe ConsortiumDr. Ruben van Eijk is an associate professor in the Department of Neurology at the University Medical Center Utrecht in the Netherlands as well as a statistical consultant and medical statistician for the clinical trial methodology group at the Julius...2219als,biomarker,clinicaltrials,health,neurology,outcomemeasures,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-13-dr-benatar-on-prognostic-markers-and-als--64437753]]>https://api.spreaker.com/episode/64437753Tue, 18 Feb 2025 19:59:34 +0000CReATe ConsortiumDr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami.  Here he discusses the recent publication “Prognostic clinical and biological markers for...]]>1591als,biomarker,clinicaltrials,health,neurofilament,neurology,prognostic,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-12-drs-jesse-crayle-and-evadnie-rampersaud-on-genetics-and-als-reversal-phenotype--63546472https://api.spreaker.com/episode/63546472Thu, 02 Jan 2025 16:39:19 +0000CReATe ConsortiumDr. Jesse Crayle is a clinical neuromuscular fellow in the Department of Neurology at Washington University in St. Louis and Dr. Evadnie Rampersaud is a Principal Bioinformatics Research Scientist at St. Jude Children’s Research Hospital.  They will...1588als,genetics,gwas,health,neurology,phenotype,pma,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-60-nuedexta--63148280https://api.spreaker.com/episode/63148280Wed, 04 Dec 2024 19:22:24 +0000CReATe ConsortiumNuedexta is a combination of dextromethorphan and quinidine, and is FDA approved for treating “pseudobulbar affect” (a symptom complex where patients lose control of their laughing and crying).  Here we summarize recent trials suggesting that Nuedexta...1498als,alternativetherapy,caregiver,dextromethorphan,health,mnd,neurology,nuedexta,patient,pba,pseudobulbaraffect,quinidine,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-59-lions-mane--62610602https://api.spreaker.com/episode/62610602Mon, 04 Nov 2024 17:35:25 +0000CReATe ConsortiumLions Mane is a mushroom that has neuroprotective, neurotrophic, antioxidant, and anti-inflammatory properties.  Here we review what is known about its use in ALS models as well as patients living with the disease.1031als,alternativetherapy,antiinflammatory,antioxidant,caregiver,health,lionsmane,mnd,neurology,neuroprotective,neurotrophic,patient,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-58-insulin--62179132https://api.spreaker.com/episode/62179132Tue, 01 Oct 2024 13:42:10 +0000CReATe ConsortiumInsulin is a hormone most commonly used to lower blood sugar in people with diabetes.  Here we talk about some theoretical ways it might help help people with ALS, as well as the lack of convincing case reports or trials and the risks.1171als,alternativetherapy,caregiver,health,insulin,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-57-caffeine--61274097https://api.spreaker.com/episode/61274097Thu, 05 Sep 2024 15:02:11 +0000CReATe ConsortiumCaffeine is a chemical most of us ingest every day.  In addition to its stimulant properties, there are some theoretical ways it could help slow ALS progression.  Here we discuss the contradictory pre-clinical models and the lack of a convincing...1303als,alternativetherapy,caffeine,caregiver,health,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-11-dr-benatar-and-the-miami-framework-for-als--61012788https://api.spreaker.com/episode/61012788Tue, 13 Aug 2024 12:13:30 +0000CReATe ConsortiumMichael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “The Miami Framework for ALS and related...1807als,biomarkers,frontotemporaldementia,ftd,health,neurology,phenotype,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-10-drs-mchutchison-and-benatar-on-cognitive-and-behavioral-changes-in-mnd--58695999https://api.spreaker.com/episode/58695999Thu, 15 Feb 2024 15:14:43 +0000CReATe ConsortiumDr. Caroline McHutchison is a Neuropsychologist and CReATe Clinical Research Scholar at the University of Edinburgh and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at...1791als,c9orf,cognition,ftd,health,mnd,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-9-drs-heatwole-and-benatar-on-patient-reported-outcome-measures-and-als--58187612https://api.spreaker.com/episode/58187612Wed, 03 Jan 2024 16:42:23 +0000CReATe ConsortiumDr. Chad Heatwole is a Professor of Neurology and the Director of the Center for Health and Technology at the University of Rochester Medical Center and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and...2162als,als-hi,diseaseburden,health,neurology,patientreportedoutcome,pro,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-56-sodium-chlorite--57649249https://api.spreaker.com/episode/57649249Wed, 15 Nov 2023 15:32:25 +0000CReATe ConsortiumSodium chlorite is an experimental drug targeting macrophage activation. It exists in different formulations. An oral formulation has potentially deadly side effects. An IV formulation called NP001 has been in recent trials targeting a subset of...1335als,alternativetherapy,caregiver,health,mnd,neurology,np001,patient,science,sodiumchloritefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-55-rituximab--57169626https://api.spreaker.com/episode/57169626Mon, 09 Oct 2023 18:15:54 +0000CReATe ConsortiumRituximab is an intravenous product that reduces B lymphocytes. It can help improve strength in patients with myasthenia gravis and multi-focal motor neuropathy, neuromuscular diseases that are caused by circulating antibodies made by B lymphocytes....758als,alternativetherapy,caregiver,health,mnd,neurology,patient,rituximab,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-54-ozone-therapy--56700733https://api.spreaker.com/episode/56700733Tue, 05 Sep 2023 15:51:41 +0000CReATe ConsortiumOzone is an oxidizing agent which has some surprisingly plausible mechanisms by which it could influence ALS progression. It can also be dangerous. The FDA has warned against using it as a treatment for any disease. Further studies are needed to...1124als,alternativetherapy,caregiver,health,mnd,neurology,ozone,patient,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-53-astaxanthin--56405100https://api.spreaker.com/episode/56405100Tue, 08 Aug 2023 15:52:14 +0000CReATe ConsortiumAstaxanthin is a naturally occurring chemical which has plausible mechanisms for treating ALS and appears reasonably safe and well tolerated in non-ALS trials. We look forward to ALS-specific trials planned later this year which should shed important...1242als,alternativetherapy,astaxanthin,caregiver,health,mnd,neurodegeneration,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-8-part-i-drs-turner-and-benatar-on-neurofilament-light-chain-as-biomarker-for-als--54290354https://api.spreaker.com/episode/54290354Mon, 12 Jun 2023 12:49:15 +0000CReATe ConsortiumDr. Martin Turner is a Professor of Clinical Neurology & Neurosciences at the University of Oxford and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the...1232als,biomarker,health,neurofilamentlightchain,neurology,nfl,research,science,therapyfalsefullhttps://www.spreaker.com/episode/create-author-series-ep-8-part-ii-drs-turner-and-benatar-on-neurofilament-light-chain-as-biomarker-for-als--54290758https://api.spreaker.com/episode/54290758Mon, 12 Jun 2023 12:49:08 +0000CReATe ConsortiumDr. Martin Turner is a Professor of Clinical Neurology & Neurosciences at the University of Oxford and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the...1529als,biomarker,health,neurofilamentlightchain,neurology,nfl,research,science,therapyfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-52-antimycobacterial-antibiotics--53707118https://api.spreaker.com/episode/53707118Mon, 01 May 2023 16:32:37 +0000CReATe ConsortiumThere is a theorized association between mycobacteria and ALS, and two published case reports described improvements in ALS-like conditions (both with atypical features) after treatment with antimycobacterial antibiotics. Here we review these in...1007als,antimycobacteria,caregiver,health,mnd,mycobacterium,neurology,paratuberculosis,patient,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-51-corticosteroids--53429573https://api.spreaker.com/episode/53429573Mon, 03 Apr 2023 15:24:16 +0000CReATe ConsortiumCorticosteroids are a class of medications with well-studied effects on the immune system and some people living with ALS have reported benefits from them online. Here we review the pre-clinical and clinical data. We conclude that there is currently...819als,caregiver,corticosteroids,glucocorticoids,health,mnd,neurology,patient,science,steroidsfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-50-butyrate--53074864https://api.spreaker.com/episode/53074864Thu, 02 Mar 2023 18:35:23 +0000CReATe ConsortiumButyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong...1560als,butyrates,caregiver,health,mnd,napb,neurology,patient,science,sodiumphenylbutyrate,tauroursodeoxycholid,tudcafalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-49-methylcobalamin--52670714https://api.spreaker.com/episode/52670714Wed, 08 Feb 2023 14:35:37 +0000CReATe ConsortiumMethylcobalamin is a specific precursor to B12 (cobalamin). It has promising mechanisms by which it could slow ALS progression. Two trials done in Japan suggest that 50mg via intramuscular injection twice weekly can slow ALS progression and prolong...1606als,b12,caregiver,health,methylcobalamin,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-7-drs-jim-caress-and-michael-benatar-on-electronic-health-records-and-als-research--52361987https://api.spreaker.com/episode/52361987Thu, 05 Jan 2023 15:46:28 +0000CReATe ConsortiumDr. Jim Caress is a Professor of Neurology at Wake Forest University and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. They will be...2209als,clinic,ehr,health,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-6-drs-mary-louise-rogers-and-michael-benatar-on-urine-biomarkers-for-als--51161441https://api.spreaker.com/episode/51161441Wed, 07 Sep 2022 12:38:52 +0000CReATe ConsortiumDr. Mary-Louise Rogers is an Associate Professor at the College of Medicine and Public Health at Flinders University and Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center...1720als,biomarker,health,neopterin,neurology,pharmacodynamic,proinflammatory,research,science,urinefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-5-dr-marc-weisskopf-and-environmental-risk-factors-in-als--50943006https://api.spreaker.com/episode/50943006Wed, 17 Aug 2022 18:55:11 +0000CReATe ConsortiumDr. Marc Weisskopf is the Cecil K. and Philip Drinker Professor of Environmental Epidemiology and Physiology at Harvard T. H. Chan School of Public Health. In this interview, he discusses his recent publication titled “Occupational lead exposure and...1959als,biomarkers,epidemiology,health,job-exposure,lead,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-4-drs-melissa-nel-and-jeannine-heckmann-and-african-genetic-diversity-in-als--50437083https://api.spreaker.com/episode/50437083Fri, 01 Jul 2022 17:23:58 +0000CReATe ConsortiumDr. Melissa Nel is a Research Fellow, and Dr. Jeannine Heckmann a Professor of Neurology, both at the University of Cape Town in South Africa. In this interview, they discuss their recent publication titled “Revealing the Mutational Spectrum in South...1474africans,als,gene-discovery,genetics,health,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-48-vitamin-c--50026471https://api.spreaker.com/episode/50026471Wed, 01 Jun 2022 15:03:09 +0000CReATe ConsortiumVitamin C is a very popular supplement in people living with ALS, perhaps due to its antioxidant mechanism, low cost, and low risk. Here we review the data on Vitamin C in ALS in hopes of helping patients make more informed decisions about it.745als,caregiver,health,mnd,neurology,patient,science,supplement,vitamincfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-47-melatonin--49642251https://api.spreaker.com/episode/49642251Tue, 03 May 2022 14:52:44 +0000CReATe ConsortiumMelatonin is a naturally occurring hormone, and it is commonly taken as a supplement to induce sleep. Here we review some surprising mechanisms, pre-clinical data and case reports supporting its potential as an ALS treatment.1081als,caregiver,health,melatonin,mnd,neurology,patient,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-46-light-therapy--49284105https://api.spreaker.com/episode/49284105Fri, 01 Apr 2022 16:47:23 +0000CReATe ConsortiumLight therapy has surprisingly plausible mechanisms through which it could influence the progression of ALS. Here we describe these, as well as some limited pre-clinical and clinical data, and information about dosing, risks, and costs.1037als,caregiver,health,mnd,neurology,patient,science,transcutaneous,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-45-ketogenic-diets--48935020https://api.spreaker.com/episode/48935020Thu, 03 Mar 2022 13:46:31 +0000CReATe ConsortiumKetogenic diets, resulting in the formation of ketone bodies, have long been used to promote weight loss and to treat refractory epilepsy. Here we summarize the available data on ketogenic diets as a treatment for ALS.998als,caregiver,health,ketogenic,mnd,neurology,patient,science,treatmentfalsefullhttps://www.spreaker.com/episode/create-author-series-ep-3-dr-michael-benatar-and-neurofilament-biomarkers-for-als--48025467https://api.spreaker.com/episode/48025467Wed, 22 Dec 2021 16:03:29 +0000CReATe ConsortiumDr. Michael Benatar is the Walter Bradley Chair in ALS Research, a Professor of Neurology at the University of Miami Miller School of Medicine and the Principal Investigator of the CReATe Consortium. In this interview, he will discuss the CReATe...2193als,biomarker,health,neurofilament,neurology,pharmacodynamic,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-2-dr-corey-mcmillan-and-cognition-in-als--47312631https://api.spreaker.com/episode/47312631Fri, 05 Nov 2021 12:45:19 +0000CReATe ConsortiumDr. Corey McMillan is an Associate Professor of Neurology at the University of Pennsylvania and this interview will be discussing his recent paper titled “Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral...1794als,cognition,ftd,health,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/create-author-series-ep-1-dr-benjamin-murdock-and-immune-mechanisms-in-als--46817908https://api.spreaker.com/episode/46817908Mon, 04 Oct 2021 17:48:18 +0000CReATe ConsortiumDr. Benjamin Murdock is a Research Assistant Professor of Neurology at the University of Michigan and this interview will be discussing his recent paper titled “NK Cells associated with ALS in a sex- and age-dependent manner” which further expands his...1449als,health,immunotherapy,neurology,research,sciencefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-44-tamoxifen--44870641https://api.spreaker.com/episode/44870641Tue, 06 Jul 2021 20:06:39 +0000CReATe ConsortiumTamoxifen is an FDA approved estrogen receptor modulator that is currently prescribed to treat breast cancer. Here we review surprising evidence that it could someday be an ALS treatment, including its mechanisms of action, pre-clinical data, cases,...1028als,caregiver,health,mnd,neurology,patient,science,supplement,tamoxifen,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-43-spirulina-blue-green-algae--44870637https://api.spreaker.com/episode/44870637Tue, 08 Jun 2021 15:00:25 +0000CReATe ConsortiumSpirulina, or blue green algae, is a supplement that is claimed to have antioxidant and anti-inflammatory properties. Here we review the problems we found with the single relevant preclinical ALS study, and some surprising real and potential risks...953algae,als,caregiver,health,mnd,neuroscience,patient,science,spirulina,supplement,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-42-lutimax--44870610https://api.spreaker.com/episode/44870610Fri, 21 May 2021 19:24:53 +0000CReATe ConsortiumLutimax is a supplement containing Luteolin, a flavonoid that has antioxidant, anti-inflammatory and neuroprotective mechanisms. Here we review case reports and a small trial claiming benefits in people with ALS.833als,health,lutimax,mnd,neurology,patient,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-41-bee-venom--44556150https://api.spreaker.com/episode/44556150Thu, 29 Apr 2021 16:58:40 +0000CReATe ConsortiumBee Venom contains substances that could plausibly affect the rate of ALS progression, and there are some positive (though flawed) preclinical studies and case reports associated with it. Since it has some potentially severe side effects and has not...755als,bee,brain,caregiver,cure,health,medicine,mnd,neurology,patient,science,treatment,venomfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-40-vinpocetine--42828991https://api.spreaker.com/episode/42828991Mon, 25 Jan 2021 13:58:51 +0000CReATe ConsortiumVinpocetine is a prescription drug in many countries and is used to treat patients with stroke and memory loss (though meta-analyses have questioned its benefit in these populations). In the USA, it is sold as a nutritional supplement. Here we...939als,brain,caregiver,health,mnd,neurology,patient,science,treatment,vinpocetinefalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-39-apoaequorin-prevagen--42828989https://api.spreaker.com/episode/42828989Thu, 07 Jan 2021 16:10:11 +0000CReATe ConsortiumApoaequorin (also called Prevagen) is a calcium binding protein first isolated from jellyfish. Here we review the theory and the single trial of this compound for treating ALS.683als,apoaequorin,brain,caregiver,health,mnd,neurology,patient,prevagen,science,therapy,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-38-azathioprine--42540369https://api.spreaker.com/episode/42540369Thu, 17 Dec 2020 18:54:22 +0000CReATe ConsortiumAzathioprine is an immunosuppressant drug. Here we review the mechanisms by which it could slow ALS progression, discuss the ALS reversals and the negative ALS trials associated with this drug, and highlight some of the serious side effects that can...952als,azathioprine,brain,caregiver,disease,health,mnd,neurology,patient,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-37-accilion--42243575https://api.spreaker.com/episode/42243575Mon, 30 Nov 2020 18:29:02 +0000CReATe ConsortiumAccilion is a topical mineral cream. Here we discuss why we do not think it has a plausible mechanism of action for treating ALS. We also point out the problems interpreting the one anecdotal report of improvement in ALS symptoms associated with...759accilion,als,caregiver,disease,health,mnd,neurology,patient,science,treamentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-36-vitamin-e--40958050https://api.spreaker.com/episode/40958050Mon, 05 Oct 2020 14:13:27 +0000CReATe ConsortiumVitamin E is one of the most popular, and most thoroughly studied, supplements in patients with ALS. Although it is inexpensive and safe, well designed trials have failed to find evidence that it can slow, stop, or reverse ALS progression....1070als,caregiver,disease,health,mnd,patient,science,supplement,treatment,vitaminfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-35-leap2bfit--40958046https://api.spreaker.com/episode/40958046Thu, 17 Sep 2020 17:37:16 +0000CReATe ConsortiumLeap2Bfit is a combination of many ingredients. The exact amount of each ingredient is not clear. While some of these products have plausible mechanisms and preclinical studies supporting their use in ALS, others do not. There are 3 "ALS reversals"...703als,caregiver,disease,health,leap2bfit,medicine,mnd,neurology,patient,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-34-ursodiol--40449299https://api.spreaker.com/episode/40449299Sat, 22 Aug 2020 13:42:14 +0000CReATe ConsortiumUrsodiol or ursodeoxycholic acid (UDCA) is a bile acid derivative of cholesterol. Since it can have antioxidant, anti-inflammatory and anti-apoptotic effects, it has mechanisms by which it could slow ALS progression. Here we discuss trials of UDCA...842als,caregiver,health,medicine,mnd,neurology,patient,science,treatment,ursodiolfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-33-propofol--40126117https://api.spreaker.com/episode/40126117Mon, 03 Aug 2020 15:49:12 +0000CReATe ConsortiumPropofol is an intravenous drug used for general anesthesia. Some people with ALS have reported benefits from this drug. Here we explore the rationale, the cases we found objective data on, and the serious risks of propofol as an ALS treatment.685als,caregiver,health,medicine,mnd,neurology,patient,propofol,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-32-l-carnitine--38457947https://api.spreaker.com/episode/38457947Fri, 10 Jul 2020 21:32:53 +0000CReATe ConsortiumCarnitines are inexpensive, generally safe forms of amino acids. There are several mechanisms by which different carnitines might theoretically be helpful to a person with ALS. A flawed Italian trial suggested that acetyl-L-carnitine could slow ALS...1033als,aminoacid,caregiver,carnitine,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-31-gluten-free-diet--28846946https://api.spreaker.com/episode/28846946Thu, 04 Jun 2020 03:53:57 +0000CReATe ConsortiumGluten is a protein found in breads and cereals. In a small percentage of people, ingestion of gluten can trigger an autoimmune disease. Here we review the evidence that gluten-induced autoimmunity can mimic ALS, as well as the pros and cons of a...422als,caregiver,diet,gluten,health,medicine,mnd,neurology,patient,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-30-mito-q--28464380https://api.spreaker.com/episode/28464380Wed, 27 May 2020 19:44:27 +0000CReATe ConsortiumIt is clear that oxidative stress is occurring in the brains and spinal cords of patients with ALS. The mitochondria are a major source and target of this oxidative stress. Here we describe an antioxidant that specifically targets mitochondria...629als,caregiver,disease,health,medicine,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-29-fecal-transplants--28464375https://api.spreaker.com/episode/28464375Wed, 27 May 2020 19:44:18 +0000CReATe ConsortiumThere is increasing evidence that the microbiome (the family of organisms that live in our guts) may play a role in driving ALS progression. Here we review the evidence behind that idea, and explore fecal transplants as one potential way to alter the...841als,caregiver,disease,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-28-list-of-rotten-eggs--28464356https://api.spreaker.com/episode/28464356Wed, 27 May 2020 19:44:05 +0000CReATe ConsortiumThis is a list of a dozen things to watch out for when considering an alternative or off label treatment being advertised on the Internet. These things tend to be associated with some of the less promising treatments that ALSUntangled has reviewed...1244als,caregiver,disease,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-27-glutathione--23291245https://api.spreaker.com/episode/23291245Fri, 28 Feb 2020 16:22:45 +0000CReATe ConsortiumGlutathione is one of the major antioxidants in all our cells. It is also one of the most popular supplements taken by patients with ALS around the world. Here we review what we learned about the mechanisms of action, pre-clinical data, case...686als,caregiver,disease,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-26-vitamin-d--22518184https://api.spreaker.com/episode/22518184Fri, 07 Feb 2020 15:41:40 +0000CReATe ConsortiumMany patients with ALS have low vitamin D levels. Here we discuss ways that vitamin D might be important in slowing ALS progression, and in reducing the risk of bone fractures from falls. We explain why we think it is important for patients with ALS...577als,caregiver,disease,health,mnd,neurology,patient,research,science,treatment,vitaminfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-25-rife-machine-and-retroviruses--22478155https://api.spreaker.com/episode/22478155Fri, 07 Feb 2020 15:41:35 +0000CReATe ConsortiumIn the 1930s, Royal Raymond Rife developed special microscopes he claimed he could visualize living microorganisms, including viruses too small to be seen with any other existing technology, via the color of auras emitted as they vibrated. He also...493als,caregiver,disease,health,medicine,mnd,neurology,patient,research,retrovirus,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-24-when-als-is-lyme--19990098https://api.spreaker.com/episode/19990098Wed, 13 Nov 2019 16:28:13 +0000CReATe ConsortiumHere we review an online manuscript called “When ALS is Lyme.” As in our previous ALSUntangled review, our large international team of clinicians and scientists again finds no convincing scientific evidence for a connection between Lyme disease and ALS.763als,caregiver,disease,health,lyme,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-23-hyperbaric-oxygen--19990095https://api.spreaker.com/episode/19990095Wed, 13 Nov 2019 16:28:10 +0000CReATe ConsortiumHyperbaric oxygen can increase heat shock proteins, which might be useful in decreasing oxidative stress and protein aggregation in ALS. It looked promising in animal models of ALS, and is associated with 1 validated case of “ALS reversal.”...888als,caregiver,health,hyperbaric,medicine,mnd,neurology,oxygen,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-22-ayahuasca--19990092https://api.spreaker.com/episode/19990092Wed, 13 Nov 2019 16:28:05 +0000CReATe ConsortiumAyahuasca is a hallucinogen used in religious rituals in the Amazon. This podcast reviews the potential mechanisms by which it might slow the progression of ALS, as well as a few case reports suggesting benefit. Unfortunately we learned this product...658als,ayahuasca,caregiver,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-21-anti-fungals--19990085https://api.spreaker.com/episode/19990085Wed, 13 Nov 2019 16:28:01 +0000CReATe ConsortiumOne group has reported evidence of fungal infections in the brains of patients who died from ALS. Here we explore the potential explanations for this finding, and the potential for anti-fungal medications as an ALS treatment.561als,antifungal,caregiver,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-20-resveratrol--18572961https://api.spreaker.com/episode/18572961Wed, 17 Jul 2019 16:19:43 +0000CReATe ConsortiumResveratrol is a naturally occurring chemical found in grapes, berries and peanuts. By modulating sirtuins, protein aggregation and the gut microbiome, it could theoretically slow ALS progression. We describe an animal study and an "ALS Reversal"...911als,caregiver,health,medicine,mnd,neurology,patient,research,resveratrol,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-19-rt001--18572950https://api.spreaker.com/episode/18572950Wed, 17 Jul 2019 16:19:40 +0000CReATe ConsortiumOxidative stress is widely believed to be one of the molecular pathways driving ALS progression. Many different antioxidants have been tried in people with ALS, with little or no previous benefit. RT001 fights oxidative stress in a unique way. Here...825als,caregiver,health,medicine,mnd,neurology,patient,research,rt001,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-18-penicillin-g-hydrocortisone--18572934https://api.spreaker.com/episode/18572934Wed, 17 Jul 2019 16:19:36 +0000CReATe ConsortiumPenicillin G is an antibiotic and hydrocortisone is an anti-inflammatory. These 2 drugs have been successfully used in combination to treat cases of syphilis mimicking ALS. Here we show 1 person's theory on why they could help people with ALS who do...790als,caregiver,health,medicine,mnd,neurology,patient,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-17-perampanel--18572909https://api.spreaker.com/episode/18572909Wed, 17 Jul 2019 16:19:31 +0000CReATe ConsortiumPerampanel (also called Fycompa) is a drug used to treat epileptic seizures. Here we review the reasons it might be useful in slowing ALS progression and describe what happened when ALS mice and a small number of people with ALS were treated with...1002als,caregiver,drug,health,medicine,mnd,neurology,patient,perampanel,research,science,seizure,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-16-acupuncture--16530061https://api.spreaker.com/episode/16530061Thu, 20 Dec 2018 12:51:46 +0000CReATe ConsortiumAcupuncture is often thought of as a treatment option for pain. In this podcast we look critically at whether acupuncture might have mechanisms that could slow ALS progression, and we review published trials of acupuncture in patients with ALS.695acupuncture,als,caregiver,health,medicine,mnd,neurology,patients,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-15-low-dose-naltrexone-for-als--16530060https://api.spreaker.com/episode/16530060Thu, 20 Dec 2018 12:51:43 +0000CReATe ConsortiumLow dose naltrexone (LDN) has been proposed as a treatment for a long list of different diseases. Here we examine the potential mechanisms, pre-clinical data and anecdotal reports on LDN in ALS.368als,caregiver,health,medicine,mnd,neurology,patients,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-14-cannabis--16530059https://api.spreaker.com/episode/16530059Thu, 20 Dec 2018 12:51:38 +0000CReATe ConsortiumMany patients over the years have told us that forms of cannabis can help bothersome ALS symptoms such as pain, cramps, fasciculations, and low appetite. Here we review theoretical, pre-clinical and anecdotal evidence that forms of cannabis might...940als,cannabis,caregiver,health,medicine,mnd,neurology,patients,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/als-untangled-series-ep-13-antiretrovirals--16530058https://api.spreaker.com/episode/16530058Thu, 20 Dec 2018 12:51:32 +0000CReATe ConsortiumSeveral observations suggest that retroviruses might be able to kill motor neurons, causing forms of ALS. Here we review these data, focusing on the theory that reactivation of an "endogenous" retrovirus we all have hiding in our genes called Herv-K...894als,antiretrovirals,caregiver,health,medicine,mnd,neurology,patients,research,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-12-deanna-protocol--15027788https://api.spreaker.com/episode/15027788Tue, 12 Jun 2018 14:39:32 +0000CReATe ConsortiumWith more than 30,000 downloads, this remains our most popular ALSUntangled review of all time. Here we review the history and evolution of this cocktail, including what has been learned about it since we published our review. We highlight the...938als,caregiver,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-11-protandim--15027786https://api.spreaker.com/episode/15027786Tue, 12 Jun 2018 14:38:34 +0000CReATe ConsortiumProtandim is an oral tablet derived from 5 different plants, which may be able to activate an antioxidant pathway in cells. This treatment is also associated with an “ALS reversal,” appears reasonably safe and inexpensive, and warrants further study...416als,caregiver,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-10-lunasin--15027777https://api.spreaker.com/episode/15027777Tue, 12 Jun 2018 14:37:48 +0000CReATe ConsortiumLunasin, a peptide first isolated from soybeans, is associated with an “ALS reversal.” We explain why we once had great hope for this as an ALS treatment. We then review the results from a recently-completed, year-long clinical trial of Lunasin in 50...1076als,caregiver,health,medicine,mnd,neurology,patient,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-9-coconut-oil--15027764https://api.spreaker.com/episode/15027764Tue, 12 Jun 2018 14:37:03 +0000CReATe ConsortiumOnce ingested, coconut oil gets converted to ketone bodies which might be able to help central nervous system cells produce more normal levels of energy, and be more resistant to ALS. Here we discuss the potential utility of coconut oil and other ways...771als,caregiver,health,medicine,mnd,neurology,patient,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-8-l-serine--14524520https://api.spreaker.com/episode/14524520Fri, 13 Apr 2018 17:38:57 +0000CReATe ConsortiumBMAA is a toxin that may cause some forms of sporadic ALS. Here we discuss how L-serine, an inexpensive, widely available amino acid supplement, might block BMAA toxicity and thus be of use for preventing or slowing ALS progression.673als,caregiver,health,medicine,mnd,neurology,patient,patients,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-7-acuscope--14524507https://api.spreaker.com/episode/14524507Fri, 13 Apr 2018 17:38:53 +0000CReATe ConsortiumAcuscope is a machine that delivers a very small amount of electric current to muscles. In this podcast we report that acuscope treatment appears fairly safe, but is expensive and has shown no clear benefit in slowing ALS.294als,caregiver,health,medicine,mnd,neurology,patient,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-6-curcumin--14524492https://api.spreaker.com/episode/14524492Fri, 13 Apr 2018 17:38:43 +0000CReATe ConsortiumCurcumin is an ingredient in the spice tumeric and in curry powder. It has multiple plausible mechanisms by which it might slow ALS progression. There are 3 people with validated ALS diagnoses who recovered significant lost motor function (ALS...514als,caregiver,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-5-inosine--14524474https://api.spreaker.com/episode/14524474Fri, 13 Apr 2018 17:38:35 +0000CReATe ConsortiumInosine is a naturally occurring oral supplement that raises blood urate levels. In this podcast, we discuss ways this might slow ALS progression and why it needs careful blood and urine monitoring759als,caregivers,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-4-copper--14182813https://api.spreaker.com/episode/14182813Wed, 07 Mar 2018 15:08:08 +0000CReATe ConsortiumCuATSM is a very promising ALS treatment that is in development. Here we discuss copper metabolism in ALS, why this specific therapy might help and why less complicated copper supplements are unlikely to be of any benefit.843als,caregivers,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-3-elysium-health-s-basis-therapy--14182810https://api.spreaker.com/episode/14182810Wed, 07 Mar 2018 15:08:01 +0000CReATe ConsortiumBasis in an over the counter supplement containing nicotinamide ribose and pterostilbene. In this podcast, we review the theories on how this might help a person with ALS, as well as the potential risks and costs involved.675als,caregivers,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-2-eric-is-winning--14182808https://api.spreaker.com/episode/14182808Wed, 07 Mar 2018 15:07:55 +0000CReATe ConsortiumIn this podcast, we discuss one of the most requested ALSUntangled reviews of all time-a complicated treatment cocktail described in a book written by a patient with slowly progressive ALS called "Eric is Winning."856als,caregivers,health,medicine,mnd,neurology,patients,science,treatmentfalsefullhttps://www.spreaker.com/episode/alsuntangled-series-ep-1-alsuntangled-untangled--14182288https://api.spreaker.com/episode/14182288Wed, 07 Mar 2018 15:07:48 +0000CReATe ConsortiumALSUntangled is an internet based program that reviews alternative and off label treatments, with the goal of helping people with ALS make more informed decisions about them. This podcast describes how the program works.640als,caregivers,health,medicine,mnd,neurology,patients,science,treatmentfalsefull